InnateDB Protein
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IDBP-10977.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PLEKHA8
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Protein Name
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pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000258679
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InnateDB Gene
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IDBG-10971 (PLEKHA8)
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Protein Structure
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Function |
Cargo transport protein that is required for apical transport from the Golgi complex. Transports AQP2 from the trans- Golgi network (TGN) to sites of AQP2 phosphorylation. Mediates the non-vesicular transport of glucosylceramide (GlcCer) from the trans-Golgi network (TGN) to the plasma membrane and plays a pivotal role in the synthesis of complex glycosphingolipids. Binding of both phosphatidylinositol 4-phosphate (PIP) and ARF1 are essential for the GlcCer transfer ability. Also required for primary cilium formation, possibly by being involved in the transport of raft lipids to the apical membrane, and for membrane tubulation. {ECO:0000269PubMed:15107860, ECO:0000269PubMed:16103222, ECO:0000269PubMed:17687330}.
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Subcellular Localization |
Cytoplasm. Golgi apparatus, trans-Golgi network membrane. Membrane; Peripheral membrane protein. Note=Mainly localized to the trans-Golgi network (TGN) but also found at the rims of Golgi cisternae. Associates with ARF1 at Golgi apparatus membranes.
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Disease Associations |
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Tissue Specificity |
Expressed in kidney cell lines. {ECO:0000269PubMed:15107860}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
3
[view]
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Protein-Protein |
2
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001849
Pleckstrin homology domain
IPR014830
Glycolipid transfer protein domain
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PFAM |
PF00169
PF08718
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PRINTS |
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PIRSF |
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SMART |
SM00233
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TIGRFAMs |
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Modification |
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SwissProt |
Q96JA3
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PhosphoSite |
PhosphoSite-Q96JA3
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
84725
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UniGene |
Hs.734170
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RefSeq |
NP_116028
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HUGO |
HGNC:30037
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OMIM |
608639
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CCDS |
CCDS5424
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HPRD |
10555
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IMGT |
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EMBL |
AF308300
AF380162
AK023180
AK294857
BC002838
BC053990
CH471073
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GenPept |
AAG48267
AAH02838
AAH53990
AAK55424
BAB14449
BAG57961
EAW93930
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