InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PRSS33

Summary

InnateDB Protein

IDBP-10983.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PRSS33

Protein Name

protease, serine, 33

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000293851

InnateDB Gene

IDBG-10981 (PRSS33)

Protein Structure

UniProt Annotation

Function

Serine protease that has amidolytic activity, cleaving its substrates before Arg residues. {ECO:0000269PubMed:12795636}.

Subcellular Localization

Secreted {ECO:0000250}.

Disease Associations

Tissue Specificity

Predominantly expressed in macrophages. Present in the spleen, small and large intestine, lung and brain (at protein level). Highly expressed in peripheral leukocytes, ovary, retina, spleen and stomach. Moderately expressed in thymus, uterus and platelets, as well as some brain tissues, such as thalamus and fetal brain. {ECO:0000269PubMed:12795636}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004252	serine-type endopeptidase activity
GO:0008236	serine-type peptidase activity

Biological Process

GO:0006508

proteolysis

Cellular Component

GO:0005615

extracellular space

Protein Structure and Domains

PDB ID

InterPro

IPR001254 Peptidase S1
IPR001314 Peptidase S1A, chymotrypsin-type
IPR009003 Trypsin-like cysteine/serine peptidase domain
IPR015420 Peptidase S1A, nudel

PFAM

PF00089
PF09342

PRINTS

PR00722

PIRSF

SMART

SM00020

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt