InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NEUROD6

Summary

InnateDB Protein

IDBP-11511.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NEUROD6

Protein Name

neurogenic differentiation 6

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000297142

InnateDB Gene

IDBG-11509 (NEUROD6)

Protein Structure

UniProt Annotation

Function

Activates E box-dependent transcription in collaboration with TCF3/E47. May be a trans-acting factor involved in the development and maintenance of the mammalian nervous system. Transactivates the promoter of its own gene (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0046983	protein dimerization activity

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0021542	dentate gyrus development
GO:0030154	cell differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

InterPro

IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
IPR016637 Transcription factor, basic helix-loop-helix, NeuroD
IPR022575 Neurogenic differentiation factor, domain of unknown function

PFAM

PF00010
PF12533

PRINTS

PIRSF

PIRSF015618

SMART

SM00353

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt