Version 5.4
Homo sapiens Protein: DGCR6
Summary
InnateDB Protein IDBP-1188.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DGCR6
Protein Name DiGeorge syndrome critical region gene 6
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000331681
InnateDB Gene IDBG-1186 (DGCR6)
Protein Structure
UniProt Annotation
Function May play a role in neural crest cell migration into the third and fourth pharyngeal pouches.
Subcellular Localization Nucleus {ECO:0000269PubMed:15821931}. Note=Predominantly nuclear.
Disease Associations
Tissue Specificity Found in all tissues examined with highest expression in liver, heart and skeletal muscle. Lower levels in pancreas and placenta. Weak expression in brain. {ECO:0000269PubMed:11157784, ECO:0000269PubMed:15821931}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 64 experimentally validated interaction(s) in this database.
Experimentally validated
Total 64 [view]
Protein-Protein 61 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
Biological Process
GO:0007155 cell adhesion
GO:0009887 organ morphogenesis
Cellular Component
GO:0005578 proteinaceous extracellular matrix
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR010849 DiGeorge syndrome critical 6
PFAM PF07324
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q14129
PhosphoSite PhosphoSite-Q14129
TrEMBL X5D7D2
UniProt Splice Variant
Entrez Gene 8214
UniGene Hs.641881
RefSeq NP_005666
HUGO HGNC:2846
OMIM 601279
CCDS CCDS13753
HPRD 03177
IMGT
EMBL AC007326 AF228707 AK315115 BC047039 CH471176 CR456434 CR542133 KJ534820 X96484
GenPept AAH47039 AAK15584 AHW56460 BAG37572 CAA65339 CAG30320 CAG46930 EAX03075 EAX03077

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca