InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TPGS1

Summary

InnateDB Protein

IDBP-12318.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TPGS1

Protein Name

chromosome 19 open reading frame 20

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000352265

InnateDB Gene

IDBG-12316 (TPGS1)

Protein Structure

UniProt Annotation

Function

May act in the targeting of the tubulin polyglutamylase complex. Required for the development of the spermatid flagellum (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, flagellum axoneme. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, flagellum basal body. Cell projection, axon. Cell projection, dendrite. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Associated with microtubules from neurites, centrosomes, basal bodies and axonemes. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008017	microtubule binding
GO:0015631	tubulin binding
GO:0070740	tubulin-glutamic acid ligase activity

Biological Process

GO:0007268	synaptic transmission
GO:0007275	multicellular organismal development
GO:0007288	sperm axoneme assembly
GO:0018095	protein polyglutamylation
GO:0030534	adult behavior
GO:0051648	vesicle localization