Version 5.4
Homo sapiens Protein: ADCY9
Summary
InnateDB Protein IDBP-12516.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ADCY9
Protein Name adenylate cyclase 9
Synonyms AC9;
Species Homo sapiens
Ensembl Protein ENSP00000294016
InnateDB Gene IDBG-12514 (ADCY9)
Protein Structure
UniProt Annotation
Function May play a fundamental role in situations where fine interplay between intracellular calcium and cAMP determines the cellular function. May be a physiologically relevant docking site for calcineurin (By similarity). {ECO:0000250}.
Subcellular Localization Membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity Expressed in multiple cells of the lung, with expression highest in airway smooth muscle. {ECO:0000269PubMed:12972952}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004016 adenylate cyclase activity
GO:0005524 ATP binding
GO:0016849 phosphorus-oxygen lyase activity
GO:0046872 metal ion binding
Biological Process
GO:0006112 energy reserve metabolic process
GO:0006171 cAMP biosynthetic process
GO:0006833 water transport
GO:0007165 signal transduction
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
GO:0007202 activation of phospholipase C activity
GO:0007268 synaptic transmission
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0009190 cyclic nucleotide biosynthetic process
GO:0034199 activation of protein kinase A activity
GO:0035556 intracellular signal transduction
GO:0044281 small molecule metabolic process
GO:0045087 innate immune response
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0055085 transmembrane transport
GO:0071377 cellular response to glucagon stimulus
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
Protein Structure and Domains
PDB ID
InterPro IPR001054 Adenylyl cyclase class-3/4/guanylyl cyclase
IPR029787 Nucleotide cyclase
PFAM PF00211
PRINTS
PIRSF
SMART SM00044
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O60503
PhosphoSite PhosphoSite-O60503
TrEMBL
UniProt Splice Variant
Entrez Gene 115
UniGene Hs.610484
RefSeq NP_001107
HUGO HGNC:240
OMIM 603302
CCDS CCDS32382
HPRD 04489
IMGT
EMBL AB011092 AF036927 AJ133123 AY028949 AY028950 AY028951 AY028952 AY028953 AY028954 AY028955 AY028956 AY028957 AY028959 BC136657 BC136658 BC151207 BC151229 CH471112 DQ005545 DQ008441
GenPept AAC24201 AAI36658 AAI36659 AAI51208 AAI51230 AAK29464 AAY21237 AAY27880 BAA25446 CAB65084 EAW85331 EAW85332

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca