InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NEFM

Summary

InnateDB Protein

IDBP-12601.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NEFM

Protein Name

neurofilament, medium polypeptide

Synonyms

NEF3; NF-M; NFM;

Species

Homo sapiens

Ensembl Protein

ENSP00000221166

InnateDB Gene

IDBG-12599 (NEFM)

Protein Structure

UniProt Annotation

Function

Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	16 [view]
Protein-Protein	14 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005198	structural molecule activity
GO:0005200	structural constituent of cytoskeleton
GO:0005515	protein binding
GO:0008017	microtubule binding

Biological Process

GO:0000226	microtubule cytoskeleton organization
GO:0008088	axon cargo transport
GO:0031133	regulation of axon diameter
GO:0033693	neurofilament bundle assembly
GO:0045104	intermediate filament cytoskeleton organization
GO:0045110	intermediate filament bundle assembly
GO:0060052	neurofilament cytoskeleton organization

Cellular Component

GO:0005882	intermediate filament
GO:0005883	neurofilament
GO:0030424	axon
GO:0031594	neuromuscular junction
GO:0043005	neuron projection
GO:0097418	neurofibrillary tangle