InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ddx3y

Summary

InnateDB Protein

IDBP-127673.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ddx3y

Protein Name

DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked

Synonyms

8030469F12Rik; D1Pas1-rs1; Dby;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000088729

InnateDB Gene

IDBG-127671 (Ddx3y)

Protein Structure

UniProt Annotation

Function

Probable ATP-dependent RNA helicase. May play a role in spermatogenesis.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:15383328}. Nucleus {ECO:0000269PubMed:15383328}. Note=Shuttles between the nucleus and the cytoplasm in an XPO1-dependent manner.

Disease Associations

Tissue Specificity

Found in heart, brain, liver, skeletal muscle, kidney and testis. Low expression detected in lung. In testis, expressed in all types of spermatogenic cells including spermatogonia, spermatocytes, spermatids and somatic Sertoli cells within the seminiferous tubules. Also expressed in Leydig cells and other interstitial cells. {ECO:0000269PubMed:15383328, ECO:0000269PubMed:8144024}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0004386	helicase activity
GO:0005524	ATP binding
GO:0008026	ATP-dependent helicase activity

Biological Process

GO:0006200

ATP catabolic process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

MGI:1349406

InterPro

IPR001650 Helicase, C-terminal
IPR011545 DNA/RNA helicase, DEAD/DEAH box type, N-terminal
IPR014001 Helicase, superfamily 1/2, ATP-binding domain
IPR014014 RNA helicase, DEAD-box type, Q motif
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00271
PF00270

PRINTS

PIRSF

SMART

SM00490
SM00487

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q62095