InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: EFCAB4B

Summary

InnateDB Protein

IDBP-12820.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EFCAB4B

Protein Name

EF-hand calcium binding domain 4B

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000252322

InnateDB Gene

IDBG-12818 (EFCAB4B)

Protein Structure

UniProt Annotation

Function

Ca(2+)-binding protein that plays a key role in store- operated Ca(2+) entry (SOCE) in T-cells by regulating CRAC channel activation. Acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca(2+) concentration. It thereby regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca(2+) resulting from opening of CRAC channels, dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex. {ECO:0000269PubMed:20418871}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:20418871}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding

Biological Process

GO:0002115	store-operated calcium entry
GO:0002376	immune system process
GO:0032237	activation of store-operated calcium channel activity
GO:0051928	positive regulation of calcium ion transport