InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ccny

Summary

InnateDB Protein

IDBP-128202.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ccny

Protein Name

cyclin Y

Synonyms

1700025H17Rik; 3110050L10Rik; 4631402G10Rik; 5730405I09Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000050001

InnateDB Gene

IDBG-128200 (Ccny)

Protein Structure

UniProt Annotation

Function

Positive regulatory subunit of the cyclin-dependent kinase CDK14/PFTK1. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by recruiting CDK14/PFTK1 to the plasma membrane and promoting phosphorylation of LRP6, leading to the activation of the Wnt signaling pathway (By similarity). Recruits CDK16 to the plasma membrane (By similarity). Positive regulatory subunit of the cyclin-dependent kinase CDK16. {ECO:0000250, ECO:0000269PubMed:22184064}.

Subcellular Localization

Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}.

Disease Associations

Tissue Specificity

Detected in brain, heart, lung, skeletal muscle, ovary, thymus and testis (at protein level). {ECO:0000269PubMed:22184064}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity
GO:0019901	protein kinase binding

Biological Process

GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0000086	G2/M transition of mitotic cell cycle
GO:0016055	Wnt signaling pathway
GO:0045737	positive regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0051301	cell division
GO:0060828	regulation of canonical Wnt signaling pathway

Cellular Component

GO:0000308	cytoplasmic cyclin-dependent protein kinase holoenzyme complex
GO:0005634	nucleus
GO:0005886	plasma membrane
GO:0070062	extracellular vesicular exosome