Version 5.4
Mus musculus Protein: Gdf7
Summary
InnateDB Protein IDBP-128344.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gdf7
Protein Name growth differentiation factor 7
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000038301
InnateDB Gene IDBG-128342 (Gdf7)
Protein Structure
UniProt Annotation
Function
Subcellular Localization Secreted {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0005515 protein binding
GO:0008083 growth factor activity
GO:0042803 protein homodimerization activity
Biological Process
GO:0007411 axon guidance
GO:0010628 positive regulation of gene expression
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0021509 roof plate formation
GO:0021527 spinal cord association neuron differentiation
GO:0021915 neural tube development
GO:0022612 gland morphogenesis
GO:0030509 BMP signaling pathway
GO:0030855 epithelial cell differentiation
GO:0030901 midbrain development
GO:0032924 activin receptor signaling pathway
GO:0040007 growth
GO:0045165 cell fate commitment
GO:0045666 positive regulation of neuron differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0048608 reproductive structure development
GO:0048754 branching morphogenesis of an epithelial tube
GO:0048853 forebrain morphogenesis
GO:0060389 pathway-restricted SMAD protein phosphorylation
GO:0060571 morphogenesis of an epithelial fold
GO:2001051 positive regulation of tendon cell differentiation
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Protein Structure and Domains
PDB ID MGI:95690
InterPro IPR001111 Transforming growth factor-beta, N-terminal
IPR001839 Transforming growth factor-beta, C-terminal
IPR002405 Inhibin, alpha subunit
IPR029034 Cystine-knot cytokine
PFAM PF00688
PF00019
PRINTS PR00669
PIRSF
SMART SM00204
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P43029
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 238057
UniGene
RefSeq NP_038555
MGI ID
MGI Symbol Gdf7
OMIM
CCDS
HPRD
IMGT
EMBL AF525752 AH010605 U08339
GenPept AAA18780 AAK30843 AAP97721

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca