InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gata6

Summary

InnateDB Protein

IDBP-128586.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gata6

Protein Name

GATA binding protein 6

Synonyms

AA410133; GATA-6;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000041774

InnateDB Gene

IDBG-128584 (Gata6)

Protein Structure

UniProt Annotation

Function

Transcriptional activator that regulates SEMA3C and PLXNA2. Involved in gene regulation specifically in the gastric epithelium (By similarity). Involved in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression (PubMed:15329343). Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions (PubMed:15329343). {ECO:0000250, ECO:0000269PubMed:15329343, ECO:0000269PubMed:19666519}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:16199866}.

Disease Associations

Tissue Specificity

Expressed in myocardium, vascular smooth muscle, gut epithelium, and osteoclasts.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	15 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001103	RNA polymerase II repressing transcription factor binding
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0008270	zinc ion binding
GO:0019901	protein kinase binding
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001701	in utero embryonic development
GO:0001889	liver development
GO:0003148	outflow tract septum morphogenesis
GO:0003309	type B pancreatic cell differentiation
GO:0003310	pancreatic A cell differentiation
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0006644	phospholipid metabolic process
GO:0007493	endodermal cell fate determination
GO:0008584	male gonad development
GO:0010468	regulation of gene expression
GO:0014898	cardiac muscle hypertrophy in response to stress
GO:0030855	epithelial cell differentiation
GO:0031016	pancreas development
GO:0032911	negative regulation of transforming growth factor beta1 production
GO:0032912	negative regulation of transforming growth factor beta2 production
GO:0035239	tube morphogenesis
GO:0035987	endodermal cell differentiation
GO:0042493	response to drug
GO:0043066	negative regulation of apoptotic process
GO:0043627	response to estrogen
GO:0045087	innate immune response (InnateDB)
GO:0045766	positive regulation of angiogenesis
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048645	organ formation
GO:0048738	cardiac muscle tissue development
GO:0051145	smooth muscle cell differentiation
GO:0051891	positive regulation of cardioblast differentiation
GO:0055007	cardiac muscle cell differentiation
GO:0060045	positive regulation of cardiac muscle cell proliferation
GO:0060430	lung saccule development
GO:0060486	Clara cell differentiation
GO:0060510	Type II pneumocyte differentiation
GO:0060575	intestinal epithelial cell differentiation
GO:0060947	cardiac vascular smooth muscle cell differentiation
GO:0070848	response to growth factor
GO:0071158	positive regulation of cell cycle arrest
GO:0071371	cellular response to gonadotropin stimulus
GO:0071456	cellular response to hypoxia
GO:0071773	cellular response to BMP stimulus