Mus musculus Protein: Gata6
InnateDB Protein IDBP-128586.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gata6
Protein Name GATA binding protein 6
Synonyms AA410133; GATA-6;
Species Mus musculus
Ensembl Protein ENSMUSP00000041774
InnateDB Gene IDBG-128584 (Gata6)
Protein Structure
UniProt Annotation
Function Transcriptional activator that regulates SEMA3C and PLXNA2. Involved in gene regulation specifically in the gastric epithelium (By similarity). Involved in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression (PubMed:15329343). Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions (PubMed:15329343). {ECO:0000250, ECO:0000269PubMed:15329343, ECO:0000269PubMed:19666519}.
Subcellular Localization Nucleus {ECO:0000269PubMed:16199866}.
Disease Associations
Tissue Specificity Expressed in myocardium, vascular smooth muscle, gut epithelium, and osteoclasts.
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 17 [view]
Protein-Protein 15 [view]
Protein-DNA 2 [view]
Protein-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001103 RNA polymerase II repressing transcription factor binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0008270 zinc ion binding
GO:0019901 protein kinase binding
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001701 in utero embryonic development
GO:0001889 liver development
GO:0003148 outflow tract septum morphogenesis
GO:0003309 type B pancreatic cell differentiation
GO:0003310 pancreatic A cell differentiation
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0006644 phospholipid metabolic process
GO:0007493 endodermal cell fate determination
GO:0008584 male gonad development
GO:0010468 regulation of gene expression
GO:0014898 cardiac muscle hypertrophy in response to stress
GO:0030855 epithelial cell differentiation
GO:0031016 pancreas development
GO:0032911 negative regulation of transforming growth factor beta1 production
GO:0032912 negative regulation of transforming growth factor beta2 production
GO:0035239 tube morphogenesis
GO:0035987 endodermal cell differentiation
GO:0042493 response to drug
GO:0043066 negative regulation of apoptotic process
GO:0043627 response to estrogen
GO:0045087 innate immune response (InnateDB)
GO:0045766 positive regulation of angiogenesis
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048645 organ formation
GO:0048738 cardiac muscle tissue development
GO:0051145 smooth muscle cell differentiation
GO:0051891 positive regulation of cardioblast differentiation
GO:0055007 cardiac muscle cell differentiation
GO:0060045 positive regulation of cardiac muscle cell proliferation
GO:0060430 lung saccule development
GO:0060486 Clara cell differentiation
GO:0060510 Type II pneumocyte differentiation
GO:0060575 intestinal epithelial cell differentiation
GO:0060947 cardiac vascular smooth muscle cell differentiation
GO:0070848 response to growth factor
GO:0071158 positive regulation of cell cycle arrest
GO:0071371 cellular response to gonadotropin stimulus
GO:0071456 cellular response to hypoxia
GO:0071773 cellular response to BMP stimulus
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
Protein Structure and Domains
PDB ID MGI:107516
InterPro IPR000679 Zinc finger, GATA-type
IPR008013 GATA-type transcription activator, N-terminal
PFAM PF00320
Post-translational Modifications
SwissProt Q61169
PhosphoSite PhosphoSite-Q61169
UniProt Splice Variant
Entrez Gene 14465
UniGene Mm.473275
RefSeq NP_034388
MGI Symbol Gata6
EMBL AB034243 AF179425 AK142381 CH466592 S82462 U51335
GenPept AAB37426 AAC52841 AAD55267 BAA95683 BAE25049 EDL22985