InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Smc6

Summary

InnateDB Protein

IDBP-128799.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Smc6

Protein Name

structural maintenance of chromosomes 6

Synonyms

2810489L22Rik; 3830418C19Rik; AA990493; AU018782; AW742439; mKIAA4103; SMC-6; Smc6l1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000020931

InnateDB Gene

IDBG-128797 (Smc6)

Protein Structure

UniProt Annotation

Function

Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:11408570}. Chromosome {ECO:0000269PubMed:11408570}. Chromosome, telomere {ECO:0000250}. Note=Associates with chromatin.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005515	protein binding
GO:0005524	ATP binding

Biological Process

GO:0000722	telomere maintenance via recombination
GO:0000724	double-strand break repair via homologous recombination
GO:0016192	vesicle-mediated transport
GO:0051276	chromosome organization
GO:0090398	cellular senescence

Cellular Component

GO:0000781	chromosome, telomeric region
GO:0005622	intracellular
GO:0005634	nucleus
GO:0005694	chromosome
GO:0005730	nucleolus
GO:0016020	membrane
GO:0016605	PML body
GO:0030915	Smc5-Smc6 complex