InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Chd7

Summary

InnateDB Protein

IDBP-128857.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Chd7

Protein Name

chromodomain helicase DNA binding protein 7

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000059079

InnateDB Gene

IDBG-128871 (Chd7)

Protein Structure

UniProt Annotation

Function

Probable transcription regulator. Maybe involved in the in 45S precursor rRNA production (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in the outflow tract of the heart, optic vesicle, facio-acoustic preganglion complex, brain, olfactory pit, and mandibular component of the first branchial arch. {ECO:0000269PubMed:16400610}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 36 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	7 [view]
Protein-DNA	8 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	36 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0004386	helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016817	hydrolase activity, acting on acid anhydrides

Biological Process

GO:0001501	skeletal system development
GO:0001568	blood vessel development
GO:0001701	in utero embryonic development
GO:0003007	heart morphogenesis
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006364	rRNA processing
GO:0007417	central nervous system development
GO:0007512	adult heart development
GO:0007605	sensory perception of sound
GO:0007626	locomotory behavior
GO:0007628	adult walking behavior
GO:0008015	blood circulation
GO:0016568	chromatin modification
GO:0021545	cranial nerve development
GO:0021553	olfactory nerve development
GO:0021772	olfactory bulb development
GO:0030217	T cell differentiation
GO:0030540	female genitalia development
GO:0035116	embryonic hindlimb morphogenesis
GO:0040018	positive regulation of multicellular organism growth
GO:0042048	olfactory behavior
GO:0042471	ear morphogenesis
GO:0042472	inner ear morphogenesis
GO:0043010	camera-type eye development
GO:0043584	nose development
GO:0048752	semicircular canal morphogenesis
GO:0048806	genitalia development
GO:0048844	artery morphogenesis
GO:0050767	regulation of neurogenesis
GO:0050890	cognition
GO:0060021	palate development
GO:0060041	retina development in camera-type eye
GO:0060123	regulation of growth hormone secretion
GO:0060173	limb development
GO:0060324	face development
GO:0060429	epithelium development

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

MGI:2444748

InterPro

IPR000330 SNF2-related
IPR000953 Chromo domain/shadow
IPR001650 Helicase, C-terminal
IPR006576 BRK domain
IPR014001 Helicase, superfamily 1/2, ATP-binding domain
IPR016197 Chromo domain-like
IPR023780 Chromo domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00176
PF00271
PF07533
PF00385

PRINTS

PIRSF

SMART

SM00298
SM00490
SM00592
SM00487

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

A2AJK6