InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pitrm1

Summary

InnateDB Protein

IDBP-128941.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pitrm1

Protein Name

pitrilysin metallepetidase 1

Synonyms

2310012C15Rik; AA410010; mKIAA1104; MP-1; MP1; Ntup1; PreP;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000021611

InnateDB Gene

IDBG-128939 (Pitrm1)

Protein Structure

UniProt Annotation

Function

ATP-independent protease that degrades mitochondrial transit peptides after their cleavage. Also degrades other unstructured peptides. Specific for peptides in the range of 10 to 65 residues. Shows a preference for cleavage after small polar residues and before basic residues, but without any positional preference (By similarity). {ECO:0000250}.

Subcellular Localization

Mitochondrion matrix {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004222	metalloendopeptidase activity
GO:0046872	metal ion binding

Biological Process

GO:0006508

proteolysis

Cellular Component

GO:0005634	nucleus
GO:0005739	mitochondrion
GO:0005759	mitochondrial matrix

Protein Structure and Domains

PDB ID

MGI:1916867

InterPro

IPR007863 Peptidase M16, C-terminal domain
IPR011249 Metalloenzyme, LuxS/M16 peptidase-like
IPR011765 Peptidase M16, N-terminal
IPR013578 Peptidase M16C associated

PFAM

PF05193
PF00675
PF08367

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8K411

PhosphoSite