InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tbc1d10c

Summary

InnateDB Protein

IDBP-129159.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tbc1d10c

Protein Name

TBC1 domain family, member 10c

Synonyms

1810062O14Rik; AI428527;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000042660

InnateDB Gene

IDBG-129155 (Tbc1d10c)

Protein Structure

UniProt Annotation

Function

Inhibits the Ras signaling pathway through its intrinsic Ras GTPase-activating protein (GAP) activity. Acts as a negative feedback inhibitor of the calcineurin signaling pathway that also mediates crosstalk between calcineurin and Ras (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005097	Rab GTPase activator activity

Biological Process

GO:0008150	biological_process
GO:0032313	regulation of Rab GTPase activity
GO:0032851	positive regulation of Rab GTPase activity

Cellular Component

GO:0005575	cellular_component
GO:0016020	membrane

Protein Structure and Domains

PDB ID

MGI:1922072

InterPro

IPR000195 Rab-GTPase-TBC domain

PFAM

PF00566

PRINTS

PIRSF

SMART

SM00164

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8C9V1

PhosphoSite

PhosphoSite-Q8C9V1

TrEMBL

UniProt Splice Variant

Entrez Gene

108995

UniGene

RefSeq

NP_848765

MGI ID

MGI Symbol

Tbc1d10c

OMIM

CCDS

CCDS37885

HPRD

IMGT

EMBL

AK038366 AK040487 AK075803 AK088119 AK131177 AK146426

GenPept

BAC30605 BAC35971 BAC40158 BAD21427 BAE20537 BAE27160