InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cluap1

Summary

InnateDB Protein

IDBP-129303.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cluap1

Protein Name

clusterin associated protein 1

Synonyms

2310030D15Rik; 2610111M03Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000043397

InnateDB Gene

IDBG-129301 (Cluap1)

Protein Structure

UniProt Annotation

Function

Required for cilia biogenesis. Appears to function within the multiple intraflagellar transport complex B (IFT-B). Key regulator of hedgehog signaling. {ECO:0000269PubMed:23351563}.

Subcellular Localization

Nucleus {ECO:0000250}. Cell projection, cilium {ECO:0000269PubMed:23351563}.

Disease Associations

Tissue Specificity

Expressed in all tissues tested including heart, kidney, skeletal muscle, eye, liver, ovary, oviduct, testes, lung and brain. Elevated levels in multiciliated cells such as the bronchioles of the lungs, ependymal cells of the brain and cells with a single primary cilia of heart and kidney. {ECO:0000269PubMed:23351563}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005515	protein binding

Biological Process

GO:0001843	neural tube closure
GO:0001947	heart looping
GO:0007224	smoothened signaling pathway
GO:0021508	floor plate formation
GO:0035082	axoneme assembly
GO:0042073	intraciliary transport
GO:0042384	cilium assembly
GO:0060972	left/right pattern formation

Cellular Component

GO:0005634	nucleus
GO:0005813	centrosome
GO:0005929	cilium
GO:0005930	axoneme
GO:0030992	intraciliary transport particle B
GO:0097542	ciliary tip
GO:0097546	ciliary base