Version 5.4
Homo sapiens Protein: CDCA2
Summary
InnateDB Protein IDBP-12951.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CDCA2
Protein Name cell division cycle associated 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000328228
InnateDB Gene IDBG-12949 (CDCA2)
Protein Structure
UniProt Annotation
Function Regulator of chromosome structure during mitosis required for condensin-depleted chromosomes to retain their compact architecture through anaphase. Acts by mediating the recruitment of phopsphatase PP1-gamma subunit (PPP1CC) to chromatin at anaphase and into the following interphase. At anaphase onset, its association with chromatin targets a pool of PPP1CC to dephosphorylate substrates. {ECO:0000269PubMed:16492807, ECO:0000269PubMed:16998479}.
Subcellular Localization Nucleus {ECO:0000269PubMed:16492807}. Note=Excluded from the nucleolus. Present in nucleoplasm throughout the G1, S and G2 stages of the cell cycle. During M phase, it becomes diffuse throughout the cell as the nuclear membrane breaks down, and faintly accumulates later on metaphase chromatin. As the cell progresses to anaphase, it accumulates on chromatin.
Disease Associations
Tissue Specificity Ubiquitously expressed. {ECO:0000269PubMed:16492807}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 6 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0007067 mitotic nuclear division
GO:0035307 positive regulation of protein dephosphorylation
Cellular Component
GO:0005634 nucleus
GO:0005694 chromosome
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q69YH5
PhosphoSite PhosphoSite-Q69YH5
TrEMBL
UniProt Splice Variant
Entrez Gene 157313
UniGene Hs.33366
RefSeq NP_689775
HUGO HGNC:14623
OMIM
CCDS CCDS6049
HPRD 13014
IMGT
EMBL AC103779 AK098670 AL833396 AL833627 BC036214 BC063651 BC085609 BC104450 BC104451 BG354575
GenPept AAH36214 AAH63651 AAH85609 AAI04451 AAI04452 BAC05374 CAH10577 CAH10585

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca