InnateDB Protein
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IDBP-12956.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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C12orf5
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Protein Name
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chromosome 12 open reading frame 5
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000179259
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InnateDB Gene
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IDBG-12954 (C12orf5)
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Protein Structure
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Function |
Fructose-bisphosphatase hydrolyzing fructose-2,6- bisphosphate as well as fructose-1,6-bisphosphate. Inhibits glycolysis by reducing cellular levels of fructose-2,6- bisphosphate. May protect cells against reactive oxygen species and against apoptosis induced by tp53. {ECO:0000269PubMed:16839880}.
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Subcellular Localization |
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
7
[view]
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Protein-Protein |
7
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0004331
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fructose-2,6-bisphosphate 2-phosphatase activity
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Biological Process |
GO:0009410
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response to xenobiotic stimulus
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GO:0010332
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response to gamma radiation
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GO:0010666
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positive regulation of cardiac muscle cell apoptotic process
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GO:0016311
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dephosphorylation
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GO:0060576
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intestinal epithelial cell development
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GO:1901525
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negative regulation of macromitophagy
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GO:2000378
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negative regulation of reactive oxygen species metabolic process
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Cellular Component |
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PDB ID |
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InterPro |
IPR013078
Histidine phosphatase superfamily, clade-1
IPR029033
Histidine phosphatase superfamily
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PFAM |
PF00300
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PRINTS |
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PIRSF |
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SMART |
SM00855
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TIGRFAMs |
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Modification |
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SwissProt |
Q9NQ88
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PhosphoSite |
PhosphoSite-Q9NQ88
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
57103
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UniGene |
Hs.598023
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RefSeq |
NP_065108
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HUGO |
HGNC:1185
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OMIM |
610775
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CCDS |
CCDS8525
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HPRD |
12610
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IMGT |
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EMBL |
AJ272206
AK313226
AY425618
BC012340
CH471116
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GenPept |
AAH12340
AAQ98969
BAG36037
CAC01127
EAW88849
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