Version 5.4
Mus musculus Protein: Slc45a2
Summary
InnateDB Protein IDBP-129569.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Slc45a2
Protein Name solute carrier family 45, member 2
Synonyms Aim-1; Aim1; blanc-sale; bls; Dbr; Matp; Oca4; uw;
Species Mus musculus
Ensembl Protein ENSMUSP00000022851
InnateDB Gene IDBG-129567 (Slc45a2)
Protein Structure
UniProt Annotation
Function Melanocyte differentiation antigen. May transport substances required for melanin biosynthesis (By similarity). {ECO:0000250}.
Subcellular Localization Melanosome membrane {ECO:0000250}; Multi- pass membrane protein {ECO:0000250}.
Disease Associations Note=Defects in Slc45a2 are the cause of the UW-dbr phenotype that results in loss of nearly all pigmentation in the homozygous state.
Tissue Specificity Melanocytes, eyes, kidney and uterus.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0007601 visual perception
GO:0042438 melanin biosynthetic process
GO:0048066 developmental pigmentation
GO:0050896 response to stimulus
GO:0055085 transmembrane transport
Cellular Component
GO:0016021 integral component of membrane
GO:0033162 melanosome membrane
Protein Structure and Domains
PDB ID MGI:2153040
InterPro IPR011701 Major facilitator superfamily
IPR016196 Major facilitator superfamily domain, general substrate transporter
PFAM PF07690
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P58355
PhosphoSite PhosphoSite-P58355
TrEMBL Q541S3
UniProt Splice Variant
Entrez Gene 22293
UniGene Mm.138278
RefSeq NP_444307
MGI ID
MGI Symbol Slc45a2
OMIM
CCDS CCDS27382
HPRD
IMGT
EMBL AC102219 AF360357 AK029155 AY034377 BC125376 BC132429 CH466581
GenPept AAI25377 AAI32430 AAK58462 AAK81713 BAC26330 EDL03287

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca