Mus musculus Protein: Dsc2 | |||||||||||
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Summary | |||||||||||
InnateDB Protein | IDBP-129633.6 | ||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||
Gene Symbol | Dsc2 | ||||||||||
Protein Name | desmocollin 2 | ||||||||||
Synonyms | AW228162; Dsc2a; Dsc2b; | ||||||||||
Species | Mus musculus | ||||||||||
Ensembl Protein | ENSMUSP00000074702 | ||||||||||
InnateDB Gene | IDBG-129629 (Dsc2) | ||||||||||
Protein Structure | |||||||||||
UniProt Annotation | |||||||||||
Function | Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. | ||||||||||
Subcellular Localization | Cell membrane; Single-pass type I membrane protein. Cell junction, desmosome. | ||||||||||
Disease Associations | |||||||||||
Tissue Specificity | In all epithelia tested and heart. | ||||||||||
Comments | |||||||||||
Interactions | |||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||
PDB ID | MGI:103221 | ||||||||||
InterPro |
IPR000233
Cadherin, cytoplasmic domain IPR002126 Cadherin IPR009122 Desmosomal cadherin IPR009124 Cadherin/Desmocollin IPR014868 Cadherin prodomain IPR015919 Cadherin-like |
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PFAM |
PF01049
PF00028 PF08758 |
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PRINTS |
PR00205
PR01818 PR01820 |
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PIRSF | |||||||||||
SMART |
SM00112
SM01055 |
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TIGRFAMs | |||||||||||
Post-translational Modifications | |||||||||||
Modification | |||||||||||
Cross-References | |||||||||||
SwissProt | P55292 | ||||||||||
PhosphoSite | PhosphoSite-P55292 | ||||||||||
TrEMBL | Q99KH1 | ||||||||||
UniProt Splice Variant | |||||||||||
Entrez Gene | 13506 | ||||||||||
UniGene | Mm.473309 | ||||||||||
RefSeq | XP_006525655 | ||||||||||
MGI ID | |||||||||||
MGI Symbol | Dsc2 | ||||||||||
OMIM | |||||||||||
CCDS | |||||||||||
HPRD | |||||||||||
IMGT | |||||||||||
EMBL | AK078887 BC004663 CH466557 L33779 X73885 | ||||||||||
GenPept | AAA79176 AAA79177 AAH04663 BAC37444 CAA52089 EDK96940 | ||||||||||