InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Glis2

Summary

InnateDB Protein

IDBP-129723.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Glis2

Protein Name

GLIS family zinc finger 2

Synonyms

Gli5; Klf16; Nkl;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000014447

InnateDB Gene

IDBG-129721 (Glis2)

Protein Structure

UniProt Annotation

Function

Can act either as a transcriptional repressor or as a transcriptional activator, depending on the cell context. Acts as a repressor of the Hedgehog signaling pathway. Represses the Hedgehog-dependent expression of Wnt4. Necessary to maintain the differentiated epithelial phenotype in renal cells through the inhibition of SNAI1, which itself induces the epithelial-to- mesenchymal transition. Represses transcriptional activation by CTNNB1 in the Wnt signaling pathway. May act by recruiting the corepressors CTBP1 and HDAC3. May be involved in neuron differentiation. {ECO:0000269PubMed:11262234, ECO:0000269PubMed:11741991, ECO:0000269PubMed:16326862, ECO:0000269PubMed:17289029, ECO:0000269PubMed:17344476, ECO:0000269PubMed:21816948}.

Subcellular Localization

Nucleus speckle. Cytoplasm.

Disease Associations

Tissue Specificity

Expressed at high levels in kidney, and at lower levels in heart and lung. {ECO:0000269PubMed:11741991}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0044212	transcription regulatory region DNA binding
GO:0046872	metal ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0007399	nervous system development
GO:0030154	cell differentiation
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045879	negative regulation of smoothened signaling pathway
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter