InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Coro7

Summary

InnateDB Protein

IDBP-129765.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Coro7

Protein Name

coronin 7

Synonyms

0610011B16Rik; AW048373; AW556392;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000048489

InnateDB Gene

IDBG-129763 (Coro7)

Protein Structure

UniProt Annotation

Function

F-actin regulator involved in anterograde Golgi to endosome transport: upon ubiquitination via 'Lys-33'-linked ubiquitin chains by the BCR(KLHL20) E3 ubiquitin ligase complex, interacts with EPS15 and localizes to the trans-Golgi network, where it promotes actin polymerization, thereby facilitating post- Golgi trafficking. May play a role in the maintenance of the Golgi apparatus morphology (By similarity). {ECO:0000250}.

Subcellular Localization

Golgi apparatus membrane {ECO:0000269PubMed:15327992}. Golgi apparatus, trans-Golgi network {ECO:0000250}. Cytoplasmic vesicle {ECO:0000269PubMed:15327992}. Cytoplasm, cytosol {ECO:0000269PubMed:15327992}. Note=Predominantly cytosolic. Detected on vesicle-like cytoplasmic structures and on the cis- Golgi. Not associated with actin filaments.

Disease Associations

Tissue Specificity

In the adult, widely expressed with highest levels in brain, thymus and kidney and low levels in skeletal and heart muscle. Not expressed in lung. In the eye, strongly expressed in the outer plexiform layer of the retina. In the intestine, expressed both in terminally differentiated epithelial cells and in crypt epithelium. In the embryo, strongest expression is seen in brain, thymus, intestine, apical epidermal layers of the skin and developing lens fibers of the eye. {ECO:0000269PubMed:15327992}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005515	protein binding

Biological Process

GO:0008150

biological_process

Cellular Component

GO:0000139	Golgi membrane
GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0016021	integral component of membrane
GO:0016023	cytoplasmic membrane-bounded vesicle