Version 5.4
Mus musculus Protein: Mtr
Summary
InnateDB Protein IDBP-129802.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mtr
Protein Name 5-methyltetrahydrofolate-homocysteine methyltransferase
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000097442
InnateDB Gene IDBG-129798 (Mtr)
Protein Structure
UniProt Annotation
Function Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008270 zinc ion binding
GO:0008705 methionine synthase activity
GO:0008898 S-adenosylmethionine-homocysteine S-methyltransferase activity
GO:0031419 cobalamin binding
GO:0046872 metal ion binding
Biological Process
GO:0009086 methionine biosynthetic process
GO:0032259 methylation
GO:0042558 pteridine-containing compound metabolic process
GO:0044237 cellular metabolic process
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:894292
InterPro IPR000489 Pterin-binding
IPR003726 Homocysteine S-methyltransferase
IPR003759 Cobalamin (vitamin B12)-binding module, cap domain
IPR004223 Vitamin B12-dependent methionine synthase, activation domain
IPR006158 Cobalamin (vitamin B12)-binding domain
IPR011005 Dihydropteroate synthase-like
IPR011822 Cobalamin-dependent methionine synthase
PFAM PF00809
PF02574
PF02607
PF02965
PF02310
PRINTS
PIRSF PIRSF000381
SMART SM01018
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A6H5Y3
PhosphoSite PhosphoSite-A6H5Y3
TrEMBL
UniProt Splice Variant
Entrez Gene 238505
UniGene Mm.490157
RefSeq NP_001074597
MGI ID
MGI Symbol Mtr
OMIM
CCDS CCDS36591
HPRD
IMGT
EMBL AK142258 BC145683 BC145685
GenPept AAI45684 AAI45686 BAE24997

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca