InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Was

Summary

InnateDB Protein

IDBP-130092.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Was

Protein Name

Wiskott-Aldrich syndrome homolog (human)

Synonyms

U42471; Wasp;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000033505

InnateDB Gene

IDBG-130090 (Was)

Protein Structure

UniProt Annotation

Function

Effector protein for Rho-type GTPases. Regulates actin filament reorganization via its interaction with the Arp2/3 complex. Important for efficient actin polymerization. Possible regulator of lymphocyte and platelet function. Mediates actin filament reorganization and the formation of actin pedestals upon infection by pathogenic bacteria.

Subcellular Localization

Cytoplasm, cytoskeleton.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 30 experimentally validated interaction(s) in this database.
They are also associated with 66 interaction(s) predicted by orthology.

Experimentally validated
Total	30 [view]
Protein-Protein	30 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	66 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding
GO:0042802	identical protein binding

Biological Process

GO:0006955	immune response
GO:0007015	actin filament organization
GO:0008154	actin polymerization or depolymerization
GO:0016197	endosomal transport
GO:0030041	actin filament polymerization
GO:0030048	actin filament-based movement
GO:0042110	T cell activation
GO:0045087	innate immune response (InnateDB)
GO:2000601	positive regulation of Arp2/3 complex-mediated actin nucleation