InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Fbxo5

Summary

InnateDB Protein

IDBP-130441.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fbxo5

Protein Name

F-box protein 5

Synonyms

2510044I10Rik; C85305; Emi1; Fbxo31;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000019907

InnateDB Gene

IDBG-130439 (Fbxo5)

Protein Structure

UniProt Annotation

Function

Regulates progression through early mitosis by inhibiting the anaphase promoting complex/cyclosome (APC). Binds to the APC activators CDC20 and FZR1/CDH1 to prevent APC activation. Can also bind directly to the APC to inhibit substrate-binding. {ECO:0000250UniProtKB:Q9UKT4, ECO:0000269PubMed:16809773}.

Subcellular Localization

Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Note=In interphase, localizes in a punctate manner in the nucleus and cytoplasm with some perinuclear concentration. In mitotic cells, localizes throughout the cell, particularly at the spindle (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	31 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019901	protein kinase binding
GO:0046872	metal ion binding

Biological Process

GO:0001556	oocyte maturation
GO:0007057	spindle assembly involved in female meiosis I
GO:0007067	mitotic nuclear division
GO:0007346	regulation of mitotic cell cycle
GO:0016050	vesicle organization
GO:0016567	protein ubiquitination
GO:0040020	regulation of meiosis
GO:0045835	negative regulation of meiosis
GO:0046785	microtubule polymerization
GO:0051225	spindle assembly
GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051442	negative regulation of ubiquitin-protein ligase activity involved in meiotic cell cycle
GO:0060565	inhibition of mitotic anaphase-promoting complex activity
GO:0060903	positive regulation of meiosis I