InnateDB Protein
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IDBP-13052.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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RAD51AP1
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Protein Name
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RAD51 associated protein 1
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Synonyms
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PIR51;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000309479
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InnateDB Gene
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IDBG-13050 (RAD51AP1)
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Protein Structure
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Function |
May participate in a common DNA damage response pathway associated with the activation of homologous recombination and double-strand break repair. Functionally cooperates with PALB2 in promoting of D-loop formation by RAD51. Binds to single and double stranded DNA, and is capable of aggregating DNA. Also binds RNA. {ECO:0000269PubMed:20871616, ECO:0000269PubMed:9396801}.
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Subcellular Localization |
Nucleus {ECO:0000250}. Note=Colocalizes with RAD51 to multiple nuclear foci. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Highly expressed in testis and thymus. Lower levels in colon and small intestine. Little or no expression in spleen, prostate, ovary and peripheral blood leukocytes. {ECO:0000269PubMed:9396801}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
15
[view]
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Protein-Protein |
11
[view]
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Protein-DNA |
4
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
GO:0000724
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double-strand break repair via homologous recombination
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GO:0006281
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DNA repair
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GO:0010569
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regulation of double-strand break repair via homologous recombination
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GO:0071479
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cellular response to ionizing radiation
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Cellular Component |
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PDB ID |
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q96B01
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PhosphoSite |
PhosphoSite-Q96B01
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TrEMBL |
F5H4V6
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UniProt Splice Variant |
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Entrez Gene |
10635
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UniGene |
Hs.730696
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RefSeq |
NP_006470
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HUGO |
HGNC:16956
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OMIM |
603070
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CCDS |
CCDS8529
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HPRD |
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IMGT |
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EMBL |
AC005832
AF006259
AK096930
AK291948
BC006992
BC016330
CH471116
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GenPept |
AAC39554
AAH06992
AAH16330
BAC04902
BAF84637
EAW88844
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