InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RAD51AP1

Summary

InnateDB Protein

IDBP-13054.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RAD51AP1

Protein Name

RAD51 associated protein 1

Synonyms

PIR51;

Species

Homo sapiens

Ensembl Protein

ENSP00000228843

InnateDB Gene

IDBG-13050 (RAD51AP1)

Protein Structure

UniProt Annotation

Function

May participate in a common DNA damage response pathway associated with the activation of homologous recombination and double-strand break repair. Functionally cooperates with PALB2 in promoting of D-loop formation by RAD51. Binds to single and double stranded DNA, and is capable of aggregating DNA. Also binds RNA. {ECO:0000269PubMed:20871616, ECO:0000269PubMed:9396801}.

Subcellular Localization

Nucleus {ECO:0000250}. Note=Colocalizes with RAD51 to multiple nuclear foci. {ECO:0000250}.

Disease Associations

Tissue Specificity

Highly expressed in testis and thymus. Lower levels in colon and small intestine. Little or no expression in spleen, prostate, ovary and peripheral blood leukocytes. {ECO:0000269PubMed:9396801}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	11 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003690	double-stranded DNA binding
GO:0003697	single-stranded DNA binding
GO:0003723	RNA binding
GO:0005515	protein binding

Biological Process

GO:0000724	double-strand break repair via homologous recombination
GO:0006281	DNA repair
GO:0006310	DNA recombination
GO:0010569	regulation of double-strand break repair via homologous recombination
GO:0071479	cellular response to ionizing radiation