InnateDB Protein
|
IDBP-131037.6
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
Nagpa
|
Protein Name
|
N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
|
Synonyms
|
AI596180; UCE;
|
Species
|
Mus musculus
|
Ensembl Protein
|
ENSMUSP00000023911
|
InnateDB Gene
|
IDBG-131035 (Nagpa)
|
Protein Structure
|
|
Function |
Catalyzes the second step in the formation of the mannose 6-phosphate targeting signal on lysosomal enzyme oligosaccharides by removing GlcNAc residues from GlcNAc-alpha-P- mannose moieties, which are formed in the first step. Also hydrolyzes UDP-GlcNAc, a sugar donor for Golgi N- acetylglucosaminyltransferases.
|
Subcellular Localization |
Golgi apparatus, Golgi stack membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network {ECO:0000250}. Note=Cis/medial Golgi.
|
Disease Associations |
|
Tissue Specificity |
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated |
Total |
2
[view]
|
Protein-Protein |
2
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
Predicted by orthology |
Total |
4 [view]
|
|
|
Molecular Function |
Accession |
GO Term |
GO:0003944
|
N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase activity
|
|
Biological Process |
|
Cellular Component |
|
PDB ID |
MGI:1351598
|
InterPro |
IPR013111
EGF-like domain, extracellular
IPR018711
Domain of unknown function DUF2233
|
PFAM |
PF07974
PF09992
|
PRINTS |
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q8BJ48
|
PhosphoSite |
PhosphoSite-
|
TrEMBL |
D3Z6C9
|
UniProt Splice Variant |
|
Entrez Gene |
27426
|
UniGene |
Mm.215641
|
RefSeq |
NP_038824
|
MGI ID |
|
MGI Symbol |
Nagpa
|
OMIM |
|
CCDS |
CCDS27933
|
HPRD |
|
IMGT |
|
EMBL |
AC124576
AF187073
AK032158
AK138035
BC039790
|
GenPept |
AAF08274
AAH39790
BAC27731
BAE23539
|
|
|