Version 5.4
Mus musculus Protein: B3galnt2
Summary
InnateDB Protein IDBP-131114.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol B3galnt2
Protein Name UDP-GalNAc:betaGlcNAc beta 1,3-galactosaminyltransferase, polypeptide 2
Synonyms A930105D20Rik; C80633; D230016N13Rik;
Species Mus musculus
Ensembl Protein ENSMUSP00000097336
InnateDB Gene IDBG-131110 (B3galnt2)
Protein Structure
UniProt Annotation
Function Beta-1,3-N-acetylgalactosaminyltransferase that synthesizes a unique carbohydrate structure, GalNAc-beta-1- 3GlcNAc, on N- and O-glycans. Has no galactose nor galactosaminyl transferase activity toward any acceptor substrate. Involved in alpha-dystroglycan (DAG1) glycosylation: acts coordinately with GTDC2/POMGnT2 to synthesize a GalNAc-beta3-GlcNAc-beta-terminus at the 4-position of protein O-mannose in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine- beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan, which is required for binding laminin G-like domain-containing extracellular proteins with high affinity (By similarity). {ECO:0000250}.
Subcellular Localization Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}.
Disease Associations
Tissue Specificity Present in testis (at protein level). In testis, it is mainly detected in the middle layers of seminiferous tubules at stages XII to II. Strongly expressed in primary and secondary spermatocytes and early round spermatids, but not in spermatogonia, elongating or elongated spermatids, or in Leydig or Sertoli cells. {ECO:0000269PubMed:14724282}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008375 acetylglucosaminyltransferase activity
GO:0008376 acetylgalactosaminyltransferase activity
GO:0008378 galactosyltransferase activity
Biological Process
GO:0006486 protein glycosylation
GO:0006493 protein O-linked glycosylation
GO:0019276 UDP-N-acetylgalactosamine metabolic process
Cellular Component
GO:0000139 Golgi membrane
GO:0005783 endoplasmic reticulum
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:2145517
InterPro IPR002659 Glycosyl transferase, family 31
PFAM PF01762
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8BG28
PhosphoSite PhosphoSite-Q8BG28
TrEMBL
UniProt Splice Variant
Entrez Gene 97884
UniGene Mm.437580
RefSeq NP_848755
MGI ID
MGI Symbol B3galnt2
OMIM
CCDS CCDS26246
HPRD
IMGT
EMBL AB116655 AK035259 AK041022 AK044785 AK084275 AK151677 AK153362 AK167635 BC085110
GenPept AAH85110 BAC29004 BAC30784 BAC32091 BAC39153 BAD13421 BAE30602 BAE31934 BAE39686

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca