Version 5.4
Mus musculus Protein: Lrrc8e
Summary
InnateDB Protein IDBP-131148.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Lrrc8e
Protein Name leucine rich repeat containing 8 family, member E
Synonyms 1810049O03Rik; C87354;
Species Mus musculus
Ensembl Protein ENSMUSP00000052055
InnateDB Gene IDBG-131146 (Lrrc8e)
Protein Structure
UniProt Annotation
Function Component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and may also conduct organic osmolytes like taurine. It is unclear whether LRRC8E constitutes a pore-forming subunit or whether it is closely associated with the pore (By similarity). {ECO:0000250}.
Subcellular Localization Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0008150 biological_process
Cellular Component
GO:0005575 cellular_component
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:1919517
InterPro IPR001611 Leucine-rich repeat
IPR003591 Leucine-rich repeat, typical subtype
IPR021040 Leucine-rich repeat-containing protein 8, N-terminal
PFAM PF00560
PF13504
PF13855
PF12534
PRINTS
PIRSF
SMART SM00369
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q66JT1
PhosphoSite PhosphoSite-Q66JT1
TrEMBL Q9CVJ5
UniProt Splice Variant
Entrez Gene 72267
UniGene Mm.25479
RefSeq NP_082451
MGI ID
MGI Symbol Lrrc8e
OMIM
CCDS CCDS22079
HPRD
IMGT
EMBL AC123029 AK007851 BC080783 CH466566
GenPept AAH80783 BAB25305 EDL21975

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca