InnateDB Protein
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IDBP-131246.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Mboat2
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Protein Name
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membrane bound O-acyltransferase domain containing 2
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Synonyms
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2810049G06Rik; AU022889; AW547221; LPCAT4; Moact2; Oact2;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000077937
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InnateDB Gene
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IDBG-131242 (Mboat2)
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Protein Structure
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Function |
Acyltransferase which mediates the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3- phosphocholine or PC) (LPCAT activity). To a lesser extent, also catalyzes the acylation of lysophosphatidylethanolamine (1-acyl- sn-glycero-3-phosphoethanolamine or LPE) into phosphatidylethanolamine (1,2-diacyl-sn-glycero-3- phosphoethanolamine or PE) (LPEAT activity). Prefers oleoyl-CoA as the acyl donor. Lysophospholipid acyltransferases (LPLATs) catalyze the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle. {ECO:0000269PubMed:18287005}.
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Subcellular Localization |
Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Endoplasmic reticulum {ECO:0000269PubMed:18287005}.
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Disease Associations |
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Tissue Specificity |
Highly expressed in epididymis, brain, testis, and ovary. {ECO:0000269PubMed:18287005}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
Accession |
GO Term |
GO:0003674
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molecular_function
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GO:0047184
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1-acylglycerophosphocholine O-acyltransferase activity
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1914466
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InterPro |
IPR004299
Membrane bound O-acyl transferase, MBOAT
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PFAM |
PF03062
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8R3I2
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PhosphoSite |
PhosphoSite-Q8R3I2
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
67216
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UniGene |
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RefSeq |
NP_001076810
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MGI ID |
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MGI Symbol |
Mboat2
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OMIM |
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CCDS |
CCDS36423
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HPRD |
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IMGT |
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EMBL |
AB297383
AB305046
AK012931
AK031824
AK033106
AK034873
AK076045
BC025020
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GenPept |
AAH25020
BAB28556
BAC27567
BAC28154
BAC28863
BAC36144
BAF93902
BAG12122
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