InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ttpa

Summary

InnateDB Protein

IDBP-131251.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ttpa

Protein Name

tocopherol (alpha) transfer protein

Synonyms

alpha-TTP;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000095845

InnateDB Gene

IDBG-131247 (Ttpa)

Protein Structure

UniProt Annotation

Function

Binds alpha-tocopherol, enhances its transfer between separate membranes, and stimulates its release from liver cells. Binds both phosphatidylinol 3,4-bisphosphate and phosphatidylinol 4,5-bisphosphate; the resulting conformation change is important for the release of the bound alpha-tocopherol. {ECO:0000269PubMed:23599266}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding
GO:0008431	vitamin E binding
GO:0019842	vitamin binding
GO:0043325	phosphatidylinositol-3,4-bisphosphate binding

Biological Process

GO:0001890	placenta development
GO:0001892	embryonic placenta development
GO:0006810	transport
GO:0007584	response to nutrient
GO:0009268	response to pH
GO:0009636	response to toxic substance
GO:0032502	developmental process
GO:0042360	vitamin E metabolic process
GO:0046909	intermembrane transport
GO:0051180	vitamin transport
GO:0051452	intracellular pH reduction
GO:0060548	negative regulation of cell death
GO:0090212	negative regulation of establishment of blood-brain barrier