Version 5.4
Mus musculus Protein: Sart1
Summary
InnateDB Protein IDBP-131417.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Sart1
Protein Name squamous cell carcinoma antigen recognized by T-cells 1
Synonyms U5-110K;
Species Mus musculus
Ensembl Protein ENSMUSP00000047397
InnateDB Gene IDBG-131415 (Sart1)
Protein Structure
UniProt Annotation
Function Plays a role in mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the spliceosome. May also bind to DNA. Appears to play a role in hypoxia-induced regulation of EPO gene expression. {ECO:0000269PubMed:10887110}.
Subcellular Localization Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity Ubiquitously expressed. Shows a high expression in fetal liver and a low expression in adult liver. {ECO:0000269PubMed:10887110}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 76 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 76 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0045585 positive regulation of cytotoxic T cell differentiation
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005794 Golgi apparatus
GO:0015030 Cajal body
GO:0071013 catalytic step 2 spliceosome
Protein Structure and Domains
PDB ID MGI:1309453
InterPro IPR005011 SART-1 protein
PFAM PF03343
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9Z315
PhosphoSite PhosphoSite-Q9Z315
TrEMBL
UniProt Splice Variant
Entrez Gene 20227
UniGene Mm.34562
RefSeq NP_058578
MGI ID
MGI Symbol Sart1
OMIM
CCDS CCDS29460
HPRD
IMGT
EMBL AB014721 AF105334 AF129931 BC028823 BC051394
GenPept AAD20645 AAD38450 AAH28823 AAH51394 BAA36583

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca