Version 5.4
Mus musculus Protein: Fhod3
Summary
InnateDB Protein IDBP-131940.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fhod3
Protein Name formin homology 2 domain containing 3
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000041361
InnateDB Gene IDBG-131938 (Fhod3)
Protein Structure
UniProt Annotation
Function May play a role in actin filament polymerization in cardiomyocytes (By similarity). Actin-organizing protein that may cause stress fiber formation together with cell elongation. {ECO:0000250, ECO:0000269PubMed:15966898}.
Subcellular Localization Cytoplasm, cytoskeleton {ECO:0000269PubMed:21149568}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000269PubMed:21149568}. Note=Main part of the protein localizes to actin fibers and the remaining part displays filamentous staining. {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed in the heart, including left ventricle, kidney, brain and skeletal muscle, including soleus and tibialis anterior (at protein level). {ECO:0000269PubMed:15966898, ECO:0000269PubMed:21149568}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0003779 actin binding
GO:0005488 binding
GO:0005515 protein binding
Biological Process
GO:0030837 negative regulation of actin filament polymerization
GO:0045214 sarcomere organization
GO:0051639 actin filament network formation
GO:0055003 cardiac myofibril assembly
Cellular Component
GO:0005730 nucleolus
GO:0005865 striated muscle thin filament
GO:0030017 sarcomere
GO:0030018 Z disc
Protein Structure and Domains
PDB ID MGI:1925847
InterPro IPR015425 Formin, FH2 domain
IPR016024 Armadillo-type fold
PFAM PF02181
PRINTS
PIRSF
SMART SM00498
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q76LL6
PhosphoSite PhosphoSite-Q76LL6
TrEMBL Q6P9T5
UniProt Splice Variant
Entrez Gene 225288
UniGene Mm.329322
RefSeq NP_780485
MGI ID
MGI Symbol Fhod3
OMIM
CCDS CCDS29104
HPRD
IMGT
EMBL AB078608 AB078609 AB100088 AK220413 BC060607 BC138046
GenPept AAH60607 AAI38047 BAC98302 BAC98303 BAC98348 BAD90459

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca