InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Irs2

Summary

InnateDB Protein

IDBP-132185.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Irs2

Protein Name

insulin receptor substrate 2

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000038514

InnateDB Gene

IDBG-132183 (Irs2)

Protein Structure

UniProt Annotation

Function

May mediate the control of various cellular processes by insulin.

Subcellular Localization

Cytoplasm, cytosol {ECO:0000269PubMed:17636024}.

Disease Associations

Tissue Specificity

Skeletal muscle, lung, brain, liver, kidney, heart and spleen.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 32 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	17 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	32 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0005158	insulin receptor binding
GO:0005515	protein binding
GO:0019901	protein kinase binding
GO:0019903	protein phosphatase binding
GO:0019904	protein domain specific binding
GO:0043548	phosphatidylinositol 3-kinase binding
GO:0071889	14-3-3 protein binding

Biological Process

GO:0002053	positive regulation of mesenchymal cell proliferation
GO:0002903	negative regulation of B cell apoptotic process
GO:0007420	brain development
GO:0008283	cell proliferation
GO:0008284	positive regulation of cell proliferation
GO:0008286	insulin receptor signaling pathway
GO:0009749	response to glucose
GO:0010748	negative regulation of plasma membrane long-chain fatty acid transport
GO:0010907	positive regulation of glucose metabolic process
GO:0030335	positive regulation of cell migration
GO:0030879	mammary gland development
GO:0030890	positive regulation of B cell proliferation
GO:0032000	positive regulation of fatty acid beta-oxidation
GO:0032024	positive regulation of insulin secretion
GO:0032869	cellular response to insulin stimulus
GO:0033673	negative regulation of kinase activity
GO:0045725	positive regulation of glycogen biosynthetic process
GO:0046326	positive regulation of glucose import
GO:0071333	cellular response to glucose stimulus
GO:1901653	cellular response to peptide