InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Col4a1

Summary

InnateDB Protein

IDBP-132202.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Col4a1

Protein Name

collagen, type IV, alpha 1

Synonyms

Bru; Col4a-1; Del(8)44H; Raw; Svc;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000033898

InnateDB Gene

IDBG-132200 (Col4a1)

Protein Structure

UniProt Annotation

Function

Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.Arresten, comprising the C-terminal NC1 domain, inhibits angiogenesis and tumor formation. The C-terminal half is found to possess the anti-angiogenic activity. Specifically inhibits endothelial cell proliferation, migration and tube formation. Inhibits expression of hypoxia-inducible factor 1alpha and ERK1/2 and p38 MAPK activation. Ligand for alpha1/beta1 integrin (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted, extracellular space, extracellular matrix, basement membrane.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005201	extracellular matrix structural constituent
GO:0005515	protein binding
GO:0048407	platelet-derived growth factor binding

Biological Process

GO:0001525	angiogenesis
GO:0001569	patterning of blood vessels
GO:0007420	brain development
GO:0007528	neuromuscular junction development
GO:0030855	epithelial cell differentiation
GO:0048514	blood vessel morphogenesis
GO:0061304	retinal blood vessel morphogenesis
GO:0061333	renal tubule morphogenesis
GO:0071230	cellular response to amino acid stimulus
GO:0071711	basement membrane organization