InnateDB Protein
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IDBP-132251.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Celf4
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Protein Name
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CUGBP, Elav-like family member 4
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Synonyms
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A230070D14Rik; Brul4; BRUNOL-4; Brunol4; C130060B05Rik;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000025117
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InnateDB Gene
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IDBG-132249 (Celf4)
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Protein Structure
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Function |
RNA-binding protein implicated in the regulation of pre- mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Promotes exclusion of both the smooth muscle (SM) and non-muscle (NM) exons in actinin pre-mRNAs. Activates the splicing of MAPT/Tau exon 10. Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Expressed strongly in skeletal muscle, heart and adipose tissue (at protein level). Expressed in the brain and cerebellum. {ECO:0000269PubMed:11158314, ECO:0000269PubMed:12438720}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
1
[view]
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
2 [view]
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Molecular Function |
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Biological Process |
GO:0000380
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alternative mRNA splicing, via spliceosome
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GO:0000381
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regulation of alternative mRNA splicing, via spliceosome
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GO:0006376
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mRNA splice site selection
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GO:0048026
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positive regulation of mRNA splicing, via spliceosome
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GO:0090394
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negative regulation of excitatory postsynaptic membrane potential
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Cellular Component |
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PDB ID |
MGI:1932407
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InterPro |
IPR000504
RNA recognition motif domain
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PFAM |
PF00076
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PRINTS |
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PIRSF |
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SMART |
SM00360
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TIGRFAMs |
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Modification |
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SwissProt |
Q7TSY6
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PhosphoSite |
PhosphoSite-Q7TSY6
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
108013
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UniGene |
Mm.416638
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RefSeq |
NP_573458
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MGI ID |
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MGI Symbol |
Celf4
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OMIM |
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CCDS |
CCDS29106
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HPRD |
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IMGT |
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EMBL |
AC121094
AC144938
AC153142
AF314173
AF515450
AK044072
AK048427
AK051458
BC048405
BC052744
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GenPept |
AAH48405
AAH52744
AAK00298
AAO22167
BAC31762
BAC33334
BAC34649
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