InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rab20

Summary

InnateDB Protein

IDBP-132562.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rab20

Protein Name

RAB20, member RAS oncogene family

Synonyms

AA536966; D8Ertd350e;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000033900

InnateDB Gene

IDBG-132560 (Rab20)

Protein Structure

UniProt Annotation

Function

Plays a role in apical endocytosis/recycling. Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and Mycobacterium. Plays a role in the fusion of phagosomes with lysosomes (By similarity). {ECO:0000250}.

Subcellular Localization

Golgi apparatus {ECO:0000250}. Cytoplasmic vesicle, phagosome {ECO:0000250}. Cytoplasmic vesicle, phagosome membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Recruited to phagosomes containing S.aureus or Mycobacterium (By similarity). Highly enriched on apical endocytic structures in polarized epithelial cells of kidney proximal tubules. {ECO:0000250}.

Disease Associations

Tissue Specificity

Present in a variety of tissues, but not in brain.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005525	GTP binding

Biological Process

GO:0006184	GTP catabolic process
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0015031	protein transport
GO:0090383	phagosome acidification
GO:0090385	phagosome-lysosome fusion

Cellular Component

GO:0005622	intracellular
GO:0005794	Golgi apparatus
GO:0016020	membrane
GO:0030670	phagocytic vesicle membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0045335	phagocytic vesicle

Protein Structure and Domains

PDB ID

MGI:102789

InterPro

IPR001806 Small GTPase superfamily
IPR003578 Small GTPase superfamily, Rho type
IPR003579 Small GTPase superfamily, Rab type
IPR005225 Small GTP-binding protein domain
IPR006689 Small GTPase superfamily, ARF/SAR type
IPR013684 Mitochondrial Rho-like
IPR020849 Small GTPase superfamily, Ras type
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00071
PF00025
PF08477

PRINTS

PR00449
PR00328

PIRSF

SMART

SM00174
SM00175
SM00173

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt