InnateDB Protein
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IDBP-132584.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Vcpip1
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Protein Name
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valosin containing protein (p97)/p47 complex interacting protein 1
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Synonyms
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4932442A08; 5730421J18Rik; 5730538E15Rik; mKIAA1850; VCIP135;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000051248
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InnateDB Gene
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IDBG-132582 (Vcpip1)
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Protein Structure
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Function |
Acts as a deubiquitinating enzyme. Necessary for VCP- mediated reassembly of Golgi stacks after mitosis. May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER). Mediates dissociation of the ternary complex containing STX5A, NSFL1C and VCP. Hydrolyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitin chains (By similarity). {ECO:0000250}.
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Subcellular Localization |
Endoplasmic reticulum {ECO:0000250}. Golgi apparatus, Golgi stack {ECO:0000250}. Note=Associated with Golgi stacks and endoplasmic reticulum. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
27 [view]
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Molecular Function |
Accession |
GO Term |
GO:0004843
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ubiquitin-specific protease activity
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1917925
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InterPro |
IPR003323
Ovarian tumour, otubain
IPR029071
Ubiquitin-related domain
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PFAM |
PF02338
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8CDG3
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PhosphoSite |
PhosphoSite-Q8CDG3
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
70675
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UniGene |
Mm.481752
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RefSeq |
NP_775619
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MGI ID |
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MGI Symbol |
Vcpip1
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OMIM |
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CCDS |
CCDS14814
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HPRD |
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IMGT |
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EMBL |
AK030104
AK077494
BC052908
BC059209
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GenPept |
AAH52908
AAH59209
BAC26787
BAC36830
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