Version 5.4
Mus musculus Protein: Atxn7
Summary
InnateDB Protein IDBP-132633.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Atxn7
Protein Name ataxin 7
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000022257
InnateDB Gene IDBG-132631 (Atxn7)
Protein Structure
UniProt Annotation
Function Involved in neurodegeneration. Acts as component of the STAGA transcription coactivator-HAT complex. Mediates the interaction of STAGA complex with the CRX and is involved in CRX- dependent gene activation (By similarity). Necessary for microtubule cytoskeleton stabilization (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000305}. Nucleus, nucleolus {ECO:0000250}. Nucleus matrix {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=In addition to a diffuse distribution throughout the nucleus, it is associated with the nuclear matrix and the nucleolus. It is able to shuttle between the nucleus and cytoplasm (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity Widely expressed in adult tissues, with the highest expression in heart, brain, liver and kidney.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 77 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 77 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003682 chromatin binding
GO:0005515 protein binding
Biological Process
GO:0000226 microtubule cytoskeleton organization
GO:0006351 transcription, DNA-templated
GO:0016578 histone deubiquitination
GO:0042326 negative regulation of phosphorylation
GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0015630 microtubule cytoskeleton
GO:0016363 nuclear matrix
Protein Structure and Domains
PDB ID MGI:2179277
InterPro IPR013243 SCA7 domain
PFAM PF08313
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8R4I1
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 246103
UniGene Mm.403666
RefSeq NP_631973
MGI ID
MGI Symbol Atxn7
OMIM
CCDS CCDS26823
HPRD
IMGT
EMBL AC116479 AF455111 AK046679
GenPept AAL84238 BAC32834

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca