InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Socs1

Summary

InnateDB Protein

IDBP-132669.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Socs1

Protein Name

suppressor of cytokine signaling 1

Synonyms

Cish1; Cish7; JAB; SOCS-1; SSI-1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000038121

InnateDB Gene

IDBG-132667 (Socs1)

Protein Structure

UniProt Annotation

Function

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein- tyrosine activity (By similarity). Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival. Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2 (By similarity). SOCS1 appears to be a negative regulator in IGF1R signaling pathway (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Cytoplasmic vesicle {ECO:0000250}. Note=Detected in perinuclear cytoplasmic vesicles upon interaction with FGFR3. {ECO:0000250}.

Disease Associations

Tissue Specificity

High expression in thymus. Lower expression in lung and spleen. Expressed in both Th1 and Th2 cells. {ECO:0000269PubMed:12242343}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 62 experimentally validated interaction(s) in this database.
They are also associated with 60 interaction(s) predicted by orthology.

Experimentally validated
Total	62 [view]
Protein-Protein	55 [view]
Protein-DNA	6 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	1 [view]
DNA-RNA	0

Predicted by orthology
Total	60 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005159	insulin-like growth factor receptor binding
GO:0005515	protein binding
GO:0019210	kinase inhibitor activity
GO:0019901	protein kinase binding

Biological Process

GO:0001932	regulation of protein phosphorylation
GO:0007259	JAK-STAT cascade
GO:0016567	protein ubiquitination
GO:0019221	cytokine-mediated signaling pathway
GO:0035556	intracellular signal transduction
GO:0040008	regulation of growth
GO:0042518	negative regulation of tyrosine phosphorylation of Stat3 protein
GO:0045087	innate immune response (InnateDB)
GO:0045444	fat cell differentiation
GO:0046426	negative regulation of JAK-STAT cascade
GO:0046627	negative regulation of insulin receptor signaling pathway
GO:0060334	regulation of interferon-gamma-mediated signaling pathway
GO:0071230	cellular response to amino acid stimulus