InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mmp7

Summary

InnateDB Protein

IDBP-133012.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mmp7

Protein Name

matrix metallopeptidase 7

Synonyms

MAT;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000018767

InnateDB Gene

IDBG-133010 (Mmp7)

Protein Structure

UniProt Annotation

Function

Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase (By similarity). {ECO:0000250}.May play a role in tissue reorganization.

Subcellular Localization

Secreted, extracellular space, extracellular matrix {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004222	metalloendopeptidase activity
GO:0008237	metallopeptidase activity
GO:0008270	zinc ion binding

Biological Process

GO:0002779	antibacterial peptide secretion
GO:0006508	proteolysis
GO:0030574	collagen catabolic process
GO:0042127	regulation of cell proliferation
GO:0042493	response to drug
GO:0042742	defense response to bacterium
GO:0050829	defense response to Gram-negative bacterium
GO:0050830	defense response to Gram-positive bacterium