Homo sapiens Protein: CHL1 | |||||||||||||||||||||
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Summary | |||||||||||||||||||||
InnateDB Protein | IDBP-13310.7 | ||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||
Gene Symbol | CHL1 | ||||||||||||||||||||
Protein Name | cell adhesion molecule with homology to L1CAM (close homolog of L1) | ||||||||||||||||||||
Synonyms | CALL; L1CAM2; | ||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||
Ensembl Protein | ENSP00000256509 | ||||||||||||||||||||
InnateDB Gene | IDBG-13308 (CHL1) | ||||||||||||||||||||
Protein Structure | |||||||||||||||||||||
UniProt Annotation | |||||||||||||||||||||
Function | Extracellular matrix and cell adhesion protein that plays a role in nervous system development and in synaptic plasticity. Both soluble and membranous forms promote neurite outgrowth of cerebellar and hippocampal neurons and suppress neuronal cell death. Plays a role in neuronal positioning of pyramidal neurons and in regulation of both the number of interneurons and the efficacy of GABAergic synapses. May play a role in regulating cell migration in nerve regeneration and cortical development. Potentiates integrin-dependent cell migration towards extracellular matrix proteins. Recruits ANK3 to the plasma membrane (By similarity). {ECO:0000250}. | ||||||||||||||||||||
Subcellular Localization | Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Soluble forms produced by cleavage/shedding also exist. {ECO:0000250}.Processed neural cell adhesion molecule L1- like protein: Secreted, extracellular space, extracellular matrix {ECO:0000250}. | ||||||||||||||||||||
Disease Associations | |||||||||||||||||||||
Tissue Specificity | Expressed in the fetal and adult brain as well as in Schwann cell culture. Also detected in adult peripheral tissues. {ECO:0000269PubMed:9799093}. | ||||||||||||||||||||
Comments | |||||||||||||||||||||
Interactions | |||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||||
PDB ID | |||||||||||||||||||||
InterPro |
IPR003598
Immunoglobulin subtype 2 IPR003599 Immunoglobulin subtype IPR003961 Fibronectin, type III IPR007110 Immunoglobulin-like domain IPR013098 Immunoglobulin I-set IPR013151 Immunoglobulin |
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PFAM |
PF00041
PF01108 PF07679 PF00047 |
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PRINTS | |||||||||||||||||||||
PIRSF | |||||||||||||||||||||
SMART |
SM00408
SM00409 SM00060 |
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TIGRFAMs | |||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||
Modification | |||||||||||||||||||||
Cross-References | |||||||||||||||||||||
SwissProt | O00533 | ||||||||||||||||||||
PhosphoSite | PhosphoSite-O00533 | ||||||||||||||||||||
TrEMBL | C9JW79 | ||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||
Entrez Gene | 10752 | ||||||||||||||||||||
UniGene | Hs.731409 | ||||||||||||||||||||
RefSeq | NP_006605 | ||||||||||||||||||||
HUGO | HGNC:1939 | ||||||||||||||||||||
OMIM | 607416 | ||||||||||||||||||||
CCDS | CCDS2556 | ||||||||||||||||||||
HPRD | 07598 | ||||||||||||||||||||
IMGT | |||||||||||||||||||||
EMBL | AB209329 AC011609 AC026187 AC066595 AF002246 BC104918 BC143496 | ||||||||||||||||||||
GenPept | AAB60937 AAI04919 AAI43497 BAD92566 | ||||||||||||||||||||