InnateDB Protein
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IDBP-133203.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Dclre1c
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Protein Name
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DNA cross-link repair 1C, PSO2 homolog (S. cerevisiae)
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000054300
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InnateDB Gene
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IDBG-133199 (Dclre1c)
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Protein Structure
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Function |
Required for V(D)J recombination, the process by which exons encoding the antigen-binding domains of immunoglobulins and T-cell receptor proteins are assembled from individual V, (D), and J gene segments. V(D)J recombination is initiated by the lymphoid specific RAG endonuclease complex, which generates site specific DNA double strand breaks (DSBs). These DSBs present two types of DNA end structures: hairpin sealed coding ends and phosphorylated blunt signal ends. These ends are independently repaired by the non homologous end joining (NHEJ) pathway to form coding and signal joints respectively. This protein likely exhibits single- strand specific 5'-3' exonuclease activity in isolation, and may acquire endonucleolytic activity on 5' and 3' hairpins and overhangs when in a complex with PRKDC. The latter activity may be required specifically for the resolution of closed hairpins prior to the formation of the coding joint. May also be required for the repair of complex DSBs induced by ionizing radiation, which require substantial end-processing prior to religation by NHEJ. {ECO:0000269PubMed:12504013, ECO:0000269PubMed:12615897, ECO:0000269PubMed:15699179}.
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Subcellular Localization |
Nucleus {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
0
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
12 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:2441769
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InterPro |
IPR001279
Beta-lactamase-like
IPR011084
DNA repair metallo-beta-lactamase
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PFAM |
PF00753
PF07522
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PRINTS |
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PIRSF |
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SMART |
SM00849
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TIGRFAMs |
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Modification |
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SwissProt |
Q8K4J0
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PhosphoSite |
PhosphoSite-Q8K4J0
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
227525
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UniGene |
Mm.447788
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RefSeq |
NP_783614
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MGI ID |
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MGI Symbol |
Dclre1c
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OMIM |
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CCDS |
CCDS15649
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HPRD |
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IMGT |
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EMBL |
AF387731
AK037126
AK052369
AK088810
AL732620
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GenPept |
AAM89119
BAC29713
BAC34960
BAC40586
CAM16038
CAM16039
CAM16040
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