InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rab32

Summary

InnateDB Protein

IDBP-133331.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rab32

Protein Name

RAB32, member RAS oncogene family

Synonyms

2810011A17Rik; AU022057;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000019974

InnateDB Gene

IDBG-133329 (Rab32)

Protein Structure

UniProt Annotation

Function

Acts as an A-kinase anchoring protein by binding to the type II regulatory subunit of protein kinase A and anchoring it to the mitochondrion. Also involved in synchronization of mitochondrial fission. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and Mycobacterium (By similarity). {ECO:0000250}.

Subcellular Localization

Mitochondrion {ECO:0000250}. Cytoplasmic vesicle, phagosome {ECO:0000250}. Cytoplasmic vesicle, phagosome membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Recruited to phagosomes containing S.aureus or Mycobacterium. {ECO:0000250}.

Disease Associations

Tissue Specificity

Widely expressed with highest levels in liver. Strong expression also found in melanocyte, platelet, mast cell and fibroblast cell lines. {ECO:0000269PubMed:14499590}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0030742	GTP-dependent protein binding
GO:0032403	protein complex binding
GO:0035650	AP-1 adaptor complex binding
GO:0035651	AP-3 adaptor complex binding

Biological Process

GO:0006184	GTP catabolic process
GO:0006886	intracellular protein transport
GO:0006913	nucleocytoplasmic transport
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0015031	protein transport
GO:0019882	antigen processing and presentation
GO:0032438	melanosome organization
GO:0035646	endosome to melanosome transport
GO:0090382	phagosome maturation

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005769	early endosome
GO:0016020	membrane
GO:0030670	phagocytic vesicle membrane
GO:0042470	melanosome
GO:0045335	phagocytic vesicle

Protein Structure and Domains

PDB ID

MGI:1915094

InterPro

IPR001806 Small GTPase superfamily
IPR002041 Ran GTPase
IPR003578 Small GTPase superfamily, Rho type
IPR003579 Small GTPase superfamily, Rab type
IPR005225 Small GTP-binding protein domain
IPR006689 Small GTPase superfamily, ARF/SAR type
IPR006762 Gtr1/RagA G protein
IPR013684 Mitochondrial Rho-like
IPR020849 Small GTPase superfamily, Ras type
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00071
PF00025
PF04670
PF08477

PRINTS

PR00449
PR00627
PR00328

PIRSF

SMART

SM00176
SM00174
SM00175
SM00173

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt