InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Iws1

Summary

InnateDB Protein

IDBP-133383.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Iws1

Protein Name

IWS1 homolog (S. cerevisiae)

Synonyms

1700069O15Rik; 3000008H23; AL117927; AW214353;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000025243

InnateDB Gene

IDBG-133381 (Iws1)

Protein Structure

UniProt Annotation

Function

Transcription factor which plays a key role in defining the composition of the RNA polymerase II (RNAPII) elongation complex and in modulating the production of mature mRNA transcripts. Acts as an assembly factor to recruit various factors to the RNAPII elongation complex and is recruited to the complex via binding to the transcription elongation factor SUPT6H bound to the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2) to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00649}.

Disease Associations

Tissue Specificity

Ubiquitous. Expressed at highest level in kidney, then testicle, large intestine, small intestine, spleen and prostate, whereas the lowest level is detected in heart. {ECO:0000269PubMed:17184735}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0003677	DNA binding
GO:0005515	protein binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006397	mRNA processing
GO:0008380	RNA splicing
GO:0010793	regulation of mRNA export from nucleus
GO:0050684	regulation of mRNA processing
GO:0051028	mRNA transport
GO:0090239	regulation of histone H4 acetylation
GO:2001253	regulation of histone H3-K36 trimethylation