Version 5.4
Mus musculus Protein: Cdnf
Summary
InnateDB Protein IDBP-133582.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cdnf
Protein Name cerebral dopamine neurotrophic factor
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000046297
InnateDB Gene IDBG-133580 (Cdnf)
Protein Structure
UniProt Annotation
Function Trophic factor for dopamine neurons. Prevents the 6- hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons. When administered after 6-OHDA-lesioning, restores the dopaminergic function and prevents the degeneration of dopaminergic neurons in substantia nigra (By similarity). {ECO:0000250}.
Subcellular Localization Secreted {ECO:0000269PubMed:17611540}.
Disease Associations
Tissue Specificity Expressed at high levels in the heart, skeletal muscle, testis and brain (at protein level). In the brain, detected in the cerebral cortex neurons through layers II to VI. In the hippocampus, detected in the CA1 to CA3 pyramidal regions and in the granule and polymorph layers of dentate gyrus. Weak expression in the striatum. In substantia nigra, detected in solitary cells that did not express tyrosine hydroxylase, a marker for dopaminergic neurons. Relatively high expression in the Purkinje cells of the cerebellum and in regions of the brain stem, including the locus coeruleus. {ECO:0000269PubMed:17611540}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0008083 growth factor activity
Biological Process
GO:0008150 biological_process
Cellular Component
GO:0005575 cellular_component
GO:0005576 extracellular region
Protein Structure and Domains
PDB ID MGI:3606576
InterPro IPR019345 Armet protein
PFAM PF10208
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8CC36
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 227526
UniGene Mm.211455
RefSeq NP_808315
MGI ID
MGI Symbol Cdnf
OMIM
CCDS CCDS15654
HPRD
IMGT
EMBL AK034009 AL732620 AL929080 BC110560
GenPept AAI10561 BAC28545 CAM16050 CAM27637

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca