InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ndp

Summary

InnateDB Protein

IDBP-133692.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ndp

Protein Name

Norrie disease (pseudoglioma) (human)

Synonyms

ND; Ndph;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000046692

InnateDB Gene

IDBG-133690 (Ndp)

Protein Structure

UniProt Annotation

Function

Activates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor. Plays a central role in retinal vascularization by acting as a ligand for FZD4 that signals via stabilizing beta-catenin (CTNNB1) and activating LEF/TCF-mediated transcriptional programs. Acts in concert with TSPAN12 to activate FZD4 independently of the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1). May be involved in a pathway that regulates neural cell differentiation and proliferation. Possible role in neuroectodermal cell-cell interaction. {ECO:0000269PubMed:15035989, ECO:0000269PubMed:19837033}.

Subcellular Localization

Secreted {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in the outer nuclear, inner nuclear and ganglion cell layers of the retina. {ECO:0000269PubMed:10452356}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005109	frizzled binding
GO:0005125	cytokine activity
GO:0005515	protein binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0001890	placenta development
GO:0016055	Wnt signaling pathway
GO:0035426	extracellular matrix-cell signaling
GO:0045893	positive regulation of transcription, DNA-templated
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0060070	canonical Wnt signaling pathway
GO:0061299	retina vasculature morphogenesis in camera-type eye