Version 5.4
Mus musculus Protein: Fundc1
Summary
InnateDB Protein IDBP-133779.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fundc1
Protein Name FUN14 domain containing 1
Synonyms 1500005J14Rik; 1810033P05Rik;
Species Mus musculus
Ensembl Protein ENSMUSP00000026016
InnateDB Gene IDBG-133777 (Fundc1)
Protein Structure
UniProt Annotation
Function Acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality control. {ECO:0000250}.
Subcellular Localization Mitochondrion outer membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0000422 mitochondrion degradation
GO:0001666 response to hypoxia
Cellular Component
GO:0005741 mitochondrial outer membrane
GO:0031307 integral component of mitochondrial outer membrane
Protein Structure and Domains
PDB ID MGI:1919268
InterPro IPR007014 FUN14
PFAM PF04930
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9DB70
PhosphoSite PhosphoSite-Q9DB70
TrEMBL H3BJ77
UniProt Splice Variant
Entrez Gene 72018
UniGene Mm.41558
RefSeq NP_082334
MGI ID
MGI Symbol Fundc1
OMIM
CCDS CCDS30035
HPRD
IMGT
EMBL AK005163 AK168868 BC012515 BC030487 BX005345 CH466584
GenPept AAH12515 AAH30487 BAB23854 BAE40687 CAM21632 EDL35721 EDL35722 EDL35723

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca